The invention discloses a two-fluid grouting water plugging construction method for a pebble layer with strong permeability. During construction, cement grout and water glass seriflux are grouted into the pebble layer with strong permeability under the low pressure of between 0.5 and 1MPa; grouting holes are arranged in a plum blossom manner; and in the cement grout, cement is ordinary silicate cement P.O.42.5R, the using amount of pure cement within the length range of grouting per meter is between 150 and 200kg, the ratio of water to cement is 0.75 to 1, and the water glass seriflux is 20 Baume degree. By the method, the problems of huge incidental expense, high difficulty and the like in water plugging construction of the pebble layer with strong permeability at the bottom of the conventional river are solved.