The invention discloses an electronic multiplying charge coupled device (CCD) sine wave driving method. A series of adjustment is performed on a sine wave code stream to obtain relations between phase differences and CCD image data mean values, and an optimal phase difference is determined by a fitted curve to correct an initial sine wave code stream. In the method, rough adjustment and fine adjustment are performed on sine wave phases to obtain a relation curve for the phase differences and the CCD image data mean values, thereby determining the phase difference corresponding to a maximum CCD image data mean value to accurately correct sine waves to obtain an optimized electronic multiplying CCD driving signal and finally fulfill the aims of optimizing system imaging and improving imaging quality; and a direct-digital-synthesizer (DDS)-based digital/analogue hybrid circuit technology is adopted, and the linear amplification of the sine waves is realized by a high frequency high voltage amplification circuit.