The invention belongs to the field of oil exploitation, and relates to a steam drive exploitation method for a heavy oil reservoir, in particular to a steam drive exploitation method of intermediate-deep layer heavy oil aided by injecting air. The method comprises the following steps of synchronously and continuously injecting steam and air in a steam injection well according to a certain mass ratio in the process of intermediate-deep layer heavy oil steam drive production, and performing a low-temperature oxidation reaction between crude oil and oxygen. According to the method disclosed by the invention, heat utilization and recovery ratio of intermediate-deep layer heavy oil steam drive can be improved; a problem of steam channeling among injection and exploitation wells can be eased, and development effect of steam drive can be improved.