The invention relates to a concrete dense column gypsum composite wallboard and concrete shearing internal wall configured high-rise mixed structure system. A concrete dense column gypsum composite wallboard is arranged on site; cavity internal concrete as well as a concrete shearing internal wall, a concrete cylindrical traffic core, a concrete floorslab and a concrete built-in surrounding beam are cast synchronously to form a mixed structure high-rise load stress system; a gypsum plate and a plate cavity internal reinforced concrete dense column take part in structural stress calculation; and the connecting part of an internal wall and an external wall, the concrete in an external wallboard cavity and the concrete shearing internal wall are cast into integrated reinforced concrete. The concrete dense column gypsum composite wallboard and concrete shearing internal wall configured high-rise mixed structure system has the advantages of energy conservation, low consumption, environmental friendliness, economy and practicability, factory-like production and integrated installation; the integrated stress performance of a building is improved by the integrated casting mixed structure form; and the gypsum plate and the plate cavity internal reinforced concrete dense column take part in structural stress calculation jointly, so safety is achieved and functions are not wasted; and the integrated modernization level of the housing industry is improved.