The invention discloses a full-automatic drum type fruit grain separation orange squeezer, which comprises two upper fruit holding drums and two lower cutting drums, wherein the upper fruit holding drum is provided with at least one group of fruit holding cups distributed on circumference along the upper fruit holding drum and residue discharging devices corresponding to the fruit holding cups and used for discharging peels; the lower cutting drum is provided with a cutting rotary shaft in the radial direction; and the external end of the cutting rotary shaft is connected with a rotary cutting head matched with the fruit holding cup on the upper fruit holding drum and used for cutting and separating orange pulp, and the internal end of the cutting rotary shaft is connected with a cutting driving device for driving the cutting rotary shaft to rotate. According to the orange squeezer, a single fruit is cut into two half spheres, the half spheres are cut by the rotary cutting heads, and the orange pulp is separated by instantaneous rotation, so that good natural shape of the pulp can be kept, the quality of the fruit grains is improved, and the yield of the fruit grains and the juice is high; and meanwhile, the orange squeezer has low power consumption, can prevent bitter substances from overflowing, and is simple in process.