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CN102309458B 海藻酸钠交联莫西沙星缓释微球、其制备方法和用途以及含有所述微球的血管靶向栓塞剂 失效 - 权利终止 复审申请

海藻酸钠交联莫西沙星缓释微球、其制备方法和用途以及含有所述微球的血管靶向栓塞剂
摘要：
一种以海藻酸钠为载体交联的含莫西沙星抗结核有效成分的缓释微球和其血管靶向栓塞剂、所述微球的其制备方法和所述微球在制备药物中的用途。所述微球包括药物载体、吸附剂、抗结核药物活性成分、加强剂和固化剂，所述载体为海藻酸钠，吸附剂为人血白蛋白或牛血清白蛋白，抗结核药物活性成分为莫西沙星，加强剂为明胶或透明质酸，二价金属阳离子钙盐或钡盐为含乙醇固化剂。该栓塞剂用于介入栓塞治疗肺结核、肺结核大咯血、肺结核空洞、肾结核、甲状腺结核、颈淋巴结核、生殖器(输卵管，子宫内膜、睾丸、附睾)结核、心包结核、胸壁结核、胸膜结核。
摘要（英）：

A sodium alginate crosslinked slow-released moxifloxacin microsphere, the preparation method of the microsphere, a vascular target embolus containing the microsphere and the use of the microsphere in preparing the vascular target embolus. The microsphere contains moxifloxacin, a drug carrier, a adsorbent, a reinforcing agent and a solidifying agent, wherein the drug carrier is sodium alginate, the adsorbent is albumin prepared from human plasma or bovine serum albumin, the reinforcing agent is gelatin or hyaluronic acid, and the solidifying agent is a divalent metal cation chosen from calcium salt or barium salt.

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