An amlodipine microsphere agent, the production method and the use thereof are disclosed. The carrier material in the microsphere is selected from polylactic acid, polylactic acid-glycolic acid copolymer or polylactic acid-glycol block copolymer. The microsphere shows a good roundness, a grain size of 1-125 [mu]m, a drug loading of more than 1.5% and an entrapment efficiency of more than 70%. The microsphere is produced by in-liquid drying.