The invention discloses a tranquilizing pillow. The pillow comprises a pillow core; the pillow core comprises a first filling structure and a second filing structure; the first filling structure comprises a filling bag and an insert bag; the insert bag is filled with a granular natural health care material and is arranged in the filling bag; the upper surface of the first filling structure is an arc convex surface; and the second filling structure is U-shaped and surrounds the third side of the first filling structure and is connected to the third side of the first filling structure. Due to a side arc design, the tranquilizing pillow is in fit with a neck, relieves pressure, and carefully protects the sleep of whole night; the granular natural health care material is filled into the pillow, and mellow and full particles are contacted with a head, so the pillow has a certain effect of massaging the head, promotes blood circulation of the head, can effectively exert the effect and greatly improve the sleep quality; and the filling bag can be replaced arbitrarily according to the sleep requirements of a user, so that the user has a comfortable sleep.