The invention discloses a lead dust stage filtering purification device, which comprises a dust storage hopper, a box body, filter drums, a sealing seat, a primary purification chamber, a pulse sprayer, a wall panel, a cell, a dust filtering block, a purification chamber and an air channel. The bottomless box body is hermetically connected with a bottom frame and communicated with the dust storage hopper; the wall panel vertically arranged in the middle divides the box body into a left cavity and a right cavity; the vertical filter drums are arranged in the right cavity through the sealing seat to form a primary filtering structure; the remaining space of the upper part forms the primary purification chamber; the dust filtering block is hermetically arranged in the left cavity through the horizontally-arranged cell to form a re-purification structure; the left cavity arranged on the re-purification structure is communicated with the primary purification chamber; the left cavity arranged under the re-purification structure forms the purification chamber; and the air channel passing through a front wall and a rear wall is arranged in the purification chamber and divided into two passages by a baffle plate arranged vertically and obliquely. By adopting a stage filtering structure, the lead dust purification rate is greatly improved, and the problem of lead dust pollution of fields of lead storage batteries, lead smelting and the like is effectively solved.