The invention provides a method for interacting cross-safety protection region information in a power communication network, which comprises the steps of: pre-writing source service information into configuration files of a requester gateway and a receiver gateway according to service names; packaging request information by a parent process of the requester gateway according a preset rule, and sending the packaged information to a parent process of the receiver gateway; judging whether required source service information exists by the parent process of the receiver gateway according to the service names in the configuration files, if yes, establishing a service channel between a requester and a receiver, and generating a pair of child processes; sending a service command to the child process of the requester gateway by the requester; sending the service command to the child process of the receiver gateway by the child process of the requester gateway, sending the service command to the receiver by the child process of the receiver gateway, sending response data received from the receiver to the child process of the requester gateway; and sending the response data to the requester by the child process of the requester gateway. The invention also provides a cross-safety region protection system in the power communication network.