The invention relates to a heath care product for preventing microthrombus from forming and a preparation method thereof. The health care product comprises the following components in part by weight: 1-3 parts of natto powder, 0.8-3 parts of grape skin extract, 8-25 parts of hawthorn powder and 3-15 parts of pomegranate powder. The health care product provided by the invention is rich in various biological active substances, such as natto kinase, resveratrol, flavone, various vitamins and minerals and the like; the biological active substances are scientifically matched to exert cooperative and synergistic action, block off different paths of forming the microthrombus and establish a defensive line for preventing cardiovascular and cerebrovascular diseases.