The invention provides a novel integrated purification process for desulfurized and denitrified fume and a device for realizing the process. According to the process, sulfur dioxide and nitrogen oxide in fume are simultaneously desorbed in the same absorption tower by spraying absorption liquid, the absorption liquid is a water solution containing a desorption absorbent, and the desorption absorbent is ammonia water. The integrated purification device for the desulfurized and denitrified fume comprises an absorption tower, an ammonia supply device and a strong oxidizer supply device, wherein the ammonia supply device is communicated with the lower part of the absorption tower, and the strong oxidizer supply device is respectively connected with a fume inlet pipeline and an aeration pipe arranged in the absorption tower. By utilizing the novel integrated purification process for the desulfurized and denitrified fume and the device for realizing the process, the purification of the fume is carried out, so that the occupying area is small, the purification efficiency is high, and the utilization value of by-products is high, and further, the economic benefit and the social benefit can be obviously increased.