The invention discloses a three-dimensional vacuum cupping device, and aims at providing a three-dimensional cupping device having a mutually cooperative structure, being capable of practical and operating, ensuring that limbs enter and exit a housing and a sealing ring without limit and abrasion, can realize reliable vacuum sealing to truncus and limbs, being convenient for use and enabling the easily-damaged sealing ring to be durable. The three-dimensional vacuum cupping device comprises a shell, a loop sealing ring, an exhaust nozzle, a soft tube and a vacuum pump, wherein the inner side of the loop sealing ring on the outer side of the port of the shell is provided with a caliber-variable support ring. The three-dimensional vacuum cupping device is suitable for treating rare and stubborn diseases such as muscularconstricture of limb joints, finger stiffness, limb cold, numbness of extremities, amyotrophy, diabetic foot, elbow arm pain and curl, capillary collapse, blood vessel disappearance and the like, and obtains a special and remarkable treatment effect which is not reported in the traditional cupping device. The treatment and the physical therapy health care function on other diseases are waiting for further experimenting and developing.