The invention relates to an adaptive adjustment of an active area for a power amplifier. One embodiment of the present invention relates to a transmission circuit configured to dynamically adjust a number of active transistor cells within the power amplifier based upon a signal quality measurement determined from a feedback. The transmission circuit comprises a transmission chain having a power amplifier configured to provide an output signal. A feedback loop extends from the output of the power, amplifier to a control circuit and is configured to provide measured information about output signal (e.g., phase, amplitude, etc.) to the control circuit. The control circuit utilizes the measured signal information to evaluate a measured signal quality of the output signal. The control circuit dynamically adjusts a number of active transistor cells within a power amplifier based upon a signal quality measurement until the power amplifier is optimized to operate at an operating point for low current and good transmission quality.