The invention discloses zileuton-containing membrane-controlled slow release pellets and a preparation method thereof. The zileuton-containing membrane-controlled slow release pellets contain quick release coated pellets and slow release coated pellets in a weight part ratio of 1:3-1:7, wherein the coated pellets consist of zileuton-containing medicated pellet cores and coatin layers wrapped outside the medicated pellet cores; and the weight part ratio of the medicated pellet cores to the coating layer is 5:1-15:1. The drup release rate of the zileuton-containing membrane-controlled slow release pellets is stable and controllable, and the clinical effectiveness is obviously improved; meanwhile, adverse effect occurrence of the gastrointestinal tract is also greatly reduced; and the pellets have a simple preparation process and high repeatability and are suitable for scale-up production.