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发明公开
CN102430128A 信号调节蛋白α在制备预防和治疗过敏反应性疾病药物中的应用 无效 - 驳回

信号调节蛋白α在制备预防和治疗过敏反应性疾病药物中的应用
摘要：
本发明属于医学生物工程技术领域。信号调节蛋白α(SIRPα)是一个抑制性受体蛋白家族成员。在免疫调节方面的作用，有报道在树突状细胞(DC)，SIRPα可抑制LPS诱导的DC成熟并抑制成熟DC分泌IL-12，且DC表面SIRPα还可通过与其在T细胞上的配体CD47的作用双向负调节T细胞和DC的功能。目前尚无文献报道SIRPα在制备预防和治疗过敏反应性疾病药物中的应用。本发明的目的在于提供信号调节蛋白α的新用途。本发明克隆了SIRPα基因，构建了质粒，可以过表达或干扰SIRPα表达。本发明提供了信号调节蛋白α在制备预防和治疗过敏反应性疾病药物中的应用。
摘要（英）：

The invention belongs to the technical field of medical bioengineering. SIRPalpha is a member of an inhibitory receptor protein family. The immunoloregulation effect of a dendritic cell (DC) has been reported, the SIRPalpha can inhibit the DC maturation induced by LPS and the IL-12 secretion of the matured DC, the SIRPalpha on the surface of the DC can bidirectionally and negatively regulate the function of a T cell and the DC through the action of the SIRPalpha with a ligand CD47 on the T cell. No application of the SIRPalpha in the preparation of medicines for preventing and treating allergic diseases is reported in literatures at present. The invention aims to provide a new purpose of the SIRPalpha. SIRPalpha gene is cloned, a plasmid is constructed, and overexpression or the SIRPalpha expression interference can be carried out in the invention. The application of the SIRPalpha in the preparation of the medicines for preventing and treating the allergic diseases is provided in the invention.

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