The invention discloses a separating and screening device for a mixture of tobacco shreds and tobacco flakes, and the device is characterized by comprising a speed regulating mechanism fixed on a frame, a transmission mechanism and a screening device, wherein the speed regulating mechanism adopts a frequency converter to drive the transmission mechanism, the transmission mechanism is used for driving a screen mesh, and the other end of the screen mesh is connected with a spring which is connected with the frame. The transmission mechanism is an eccentric transmission mechanism, and the eccentric transmission mechanism is used for driving the screen mesh. Screen holes for separating scraps in the mixture and rake nails for separating the tobacco flakes from the tobacco shreds are arranged above the screen mesh. Compared with the prior art, the separating and screening device can be applied in the whole thread-making process for processing a separation task against the mixture of the tobacco flakes and the tobacco shreds, the tobacco flakes, obacco shreds and scraps in the mixture can be separated through the separation of the device, and the separated materials can be processed alone, so that the waste of the materials is avoided and the effect of reducing the consumption of tobacco leaves is achieved.