The invention relates to the technical field of a method for preparing an N-substituted oxazolone chiral ligand. The method for preparing the N-substituted oxazolone chiral ligand provided by the invention comprises the following steps of: reacting a compound A shown as the following formula (described in the specification) with R1-COC1 under the action of alkaline reagent potassium tert-butoxide, sodium methyoxide or NaNH2 to obtain a target product (I), wherein R1 is an alkyl with the number of carbon atoms of being less than or equal to 7, and R2 is phenyl, benzyl or isopropyl. In the invention, potassium tert-butoxide is used for substituting butyl lithium and lithium bis(trimethylsilyl)amide which are frequently used in the prior art, reaction can be carried out at normal temperature, reaction time is shortened, reaction is completed after batch charging is completed, then aftertreatment operation can be carried out, and dynamic cost is saved; less gas is released in the aftertreatment process, and safety is high; and yield of the obtained target compound is high, and purity is high, thus the method provided by the invention is applicable to industrial production.