The invention discloses a virtual machine management system and a use method thereof. The system comprises a central management server, host nodes and slave nodes. The central management server is used for managing the host nodes; each host node is used for managing one or more clusters, wherein each cluster comprises one or more slave nodes; and the slave nodes are physical host machines for operating virtual machines. With the adoption of the virtual machine management system and the use method of the virtual machine management system, an effect that the virtual machines can be effectively managed when the number of the virtual machines is larger is achieved.