The invention relates to the field of medicinal chemistry and discloses a compound artemisinin piperaquine pellet and a preparation method thereof. The compound artemisinin piperaquine pellet of the invention comprises 20-100 weight parts of artemisinin compound, 100-500 parts of piperaquine phosphate, 50-300 weight parts of lactose, 50-300 weight parts of microcrystalline cellulose, 10-100 weight parts of crosslinking polyvinylpyrrolidone, 0-50 weight parts of sodium carboxymethyl starch, 1-20 weight parts of polyvinylpyrrolidone and 0.05-5 weight parts of solubilizer. The compound artemisinin piperaquine pellet of the invention has regular profile, good moulding and roundness, good fluidity, stable dissolving tine, unacted dissolution and covered bitter taste, and is convenient for administration and especially suitable for children, and has wide application scope.