The invention relates to a preparation method of polynosic fabric with skin caring and calming functions. The method comprises the following steps of: (1) firstly adding neroli essential oil into polyurethane and water and stirring; adding a microcapsule solution and stirring into an emulsion form; and sequentially adding a dispersing agent, an adhesion agent and a softening agent, and stirring to obtain a neroli essential oil microcapsule finishing agent; (2) coating the neroli essential oil microcapsule finishing agent on the polynosic to obtain the polynosic with neroli essential oil microcapsules; and (3) preparing the polynosic with neroli essential oil microcapsules into yarn, preparing the yarn into fabric, and performing pre-determined locking to obtain the polynosic fabric with skin caring and calming functions. The preparation method provided by the invention is simple to operate, and prepares the microcapsule finishing agent from the all-natural extract neroli essential oil, thereby being safe and environment-friendly; and moreover, the polynosic fabric with skin caring and calming functions, prepared by the method, can uniformly release neroli flavor for a long time, and has wide application prospects.