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发明授权
CN102512448B DC-CIK细胞在制备抗HIV感染的药物中的应用 失效 - 权利终止

DC-CIK细胞在制备抗HIV感染的药物中的应用
摘要：
本发明属于生物医药领域，公开了DC-CIK细胞在制备抗HIV感染的药物中的应用。发明人通过大量实验发现：受到HIV冲击的CIK细胞在和DC细胞共培养时可以明显促进DC细胞的成熟。当DC和CIK细胞联合使用具有相互促进的提呈和杀灭受HIV感染细胞的作用。在DC-CIK细胞回输的30天后，HIV感染者CD4T细胞的数量显著升高，NK和CIK细胞杀伤功能增强，HIV病毒载量明显得到抑制。因此，共培养的树突状细胞和细胞因子诱导的杀伤细胞可在制备抗HIV感染的药物中应用。
摘要（英）：

The invention belongs to the field of biomedicine and discloses application of DC-CIK cells in preparation of a medicine used for resisting HIV infection. Through a lot of experiments, the inventor discovers that when CIK cells impacted by HIV and DC cells are co-cultured, the CIK cells can obviously promote maturation of the DC cells. When the DC and CIK cells are combined for use, the DC and CIK cells have mutual promotion presentation and a function for killing cells infected by HIV. After 30 days of the DC-CIK cell infusion, the number of CD4T cells of a HIV infector is obviously increased, the killing function of NK (Natural Killer) and CIK cells is enhanced, and HIV viral load is obviously restrained. Thus, kill cells induced by co-cultured dendritic cells and cytokines can be applied to the preparation of the medicine used for resisting HIV infection.

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