The invention discloses a polyacrylamide oil-soluble crosslinking agent which has the following structural formula: in an A3+(OOC-R)3 formula, A3+ is trivalent metal ions of aluminum, chromium and nickel; and R is chain hydrocarbon of 4-30 carbon atoms, naphthenic hydrocarbon of 4-30 carbon atoms and aromatic hydrocarbon of 4-30 carbon atoms. The invention has the beneficial effects that the polyacrylamide oil-soluble crosslinking agent is soluble in oil, is preferentially distributed in an oil phase in an oil layer and is isolated from polyacrylamide in water solution so as not to form jelly, and the crosslinking agent is dispersed in the polyacrylamide when no oil exists or less oil exists and is gradually reacted with the polyacrylamide to form the jelly so as to achieve the effects of water shutoff and profile control; the selectivity of water shutoff and profile control of a cross-linked polymer is improved; and the hydrolyzed polyacrylamide crosslinking agent is mainly applied.