The invention provides ferrite refractory steel for a vane of a steam turbine of an ultra supercritical fossil power plant, which is characterized by comprising the following chemical components calculated according to mass percent: 10.0 to 12.0 of chromium, 0.1 to 0.6 of molybdenum, 2.4 to 3.0 of tungsten, 1.0 to 4.0 of cobalt, 0 to 0.5 of nickel, 0.2 to 1.0 of manganese, 0.01 to 0.06 of nitrogen, 0.10 to 0.30 of vanadium, 0.03 to 0.10 of niobium, 0.005 to 0.015 of titanium, 0.06 to 0.15 of carbon, 0.008 to 0.015 of boron, 0.002 to 0.01 percent of zirconium and the balance as iron and unavoidable impurities; A manufacturing method of the ferrite refractory steel for the vane of the steam turbine of the ultra supercritical fossil power plant comprises the following steps: processing the compositions of the raw materials of the constituent elements sequentially by smelting and pouring so as to obtain a steel ingot of the refractory steel, then forging the steel ingot and finally, carrying out heat treatment; and the ferrite refractory steel for the vane of the steam turbine of the ultra supercritical fossil power plant and the manufacturing method are characterized in that a heat-treatment process comprises the steps of keeping oil cooling for 0.5 to 1h at 1050 to 1150 DEG C and keeping air cooling for 1 to 2h at 720 to 790 DEG C. The refractory steel has favorable corrosion resistance and creep resistance at high temperature, has stable tissues in the high-temperature long-time use procedure and can be used as a material of a vane for a steam turbine of an ultra supercritical fossil power plant above 620 DEG C.