The invention discloses a pool mixed culture method for takifugu obscurus offspring seeds and paracanthobrama guichenoti offspring seeds. Paracanthobrama guichenoti offspring seeds artificially propagated in early April and the takifugu obscurus offspring seeds bred at the end of April are placed into a pool for breeding to be subjected to the pool mixed culture; then, feeding steps of rotifers, blood worms and batch materials are adopted until the takifugu obscurus initial feed batch materials are directly adopted for feeding; and meanwhile, the whole culture process is subjected to daily management. The culture method for the takifugu obscurus offspring seeds provided by the invention does not have obvious differences from major culture on the culture specification, the unit yield, the survival rate and the like. Residue baits of the takifugu obscurus can be utilized by the paracanthobrama guichenoti on the basis of not increasing the feed cost or influencing the major culture varieties, a water quality purification effect is reached, in addition, the natural baits at the bottom layer of the water body can also be sufficiently eaten, the feed conversion rate is improved, the integral yield is improved, and great popularization values are realized. A new high-efficient large-scale culture path for brand-name and high-quality fishes such as takifugu obscurus offspring seeds and paracanthobrama guichenoti is successfully opened up.