A sea cucumber bait prepared from harmful organisms of the invention comprises the following components: dry asteroid powder, Sargassum thunbergii powder, gulfweed powder, Zostera marina powder, Ulva powder, Spirulina powder, shell powder and dry sea mud at a mass ratio of 25-35:5-15:5-15:5-15: 5-15:4-6:4-6:15-25. Each powder is of 8-200 mesh. Compared with the prior bait containing a huge amount of artificially synthetic materials, the sea cucumber bait of the invention has the advantages of wide material resource, natural ingredients, low cost, simple preparation process, convenience for eating and rich nutrition.