The invention discloses a pharmaceutical composition containing lappaconitine and iodine and relates to the use of a composition of therapeutically and/or prophylactically effective amount of lappaconitine or a pharmaceutically-acceptable salt thereof and iodine or a clathrate or complex compound thereof for preparation of medicaments for treating and/or preventing oral and throat inflammatory diseases. The invention further relates to a pharmaceutical composition which contains therapeutically and/or prophylactically effective amount of lappaconitine or a pharmaceutically-acceptable salt thereof, iodine or a clathrate or complex compound thereof and pharmaceutically-acceptable carriers. The pharmaceutical composition has antibacterial, anti-inflammatory and analgesic effects.