An isostatic pressing copper-clad plate laminating method comprises the steps as follows: stacking and fixing substrate, a bonding sheet and copper foil in sequence; vacuumizing; placing the substrate, the bonding sheet and the copper foil in a pressure vessel, starting a medium conveying pump, opening a fluid supplementation valve, filling medium into the pressure vessel and pressurizing to a certain value; closing the fluid supplementation valve, and opening a circulating valve to circulating liquid; starting a heater to heat the medium; controlling required pressure and temperature by adjusting an electric pressure regulation actuator and a temperature regulation actuator through a computer; and stopping heating after solidification, turning on cooling water to cool the medium through a cooler, and cooling to reduce the temperature to the ordinary temperature. An isostatic pressing copper-clad plate laminating device comprises the pressure vessel, the medium conveying pump, the heater, the computer, the cooler and a storage tank. The invention has the benefits that waste of energy is avoided, the medium can be recycled, produced products are uniform in thickness, and the glue is prevented from flowing from the edge.