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发明公开
CN102558076A 1-氧-2-羟甲基-3-(1-羟乙基)-喹噁啉及其制备方法和应用 失效 - 权利终止

1-氧-2-羟甲基-3-(1-羟乙基)-喹噁啉及其制备方法和应用
摘要：
本发明公开了一种1-氧-2-羟甲基-3-(1-羟乙基)-喹噁啉及其制备方法和应用。所述1-氧-2-羟甲基-3-(1-羟乙基)-喹噁啉具有如式（Ⅰ）所示结构。所述产物（Ⅰ）的制备方法是以乙酰甲喹为原料，通过还原得到1,4-二氧-3-甲基-2-（1-羟乙基）喹噁啉；然后与乙酸酐、吡啶混合反应得到1,4-二氧-2-(1-乙氧羰基氧乙基)-3-甲基-喹噁啉；接着在乙酸酐作用下，得到1-氧-2-(1-乙氧羰基氧乙基)-3-(1-乙氧羰基氧甲基)-喹噁啉，然后经过氧化剂的氧化作用和碱液的水解作用，得到1,4-二氧-2-(1-羟乙基)-3-羟甲基-喹噁啉，最后通过还原剂还原获得得到产物（Ⅰ）。所述的产物（Ⅰ）可以作为乙酰甲喹在靶动物体内代谢的残留标示物或是作为在动物源性食品中检测乙酰甲喹残留的标准品或对照品。（Ⅰ）
摘要（英）：

The invention discloses 1-oxygen-2-hydroxylmethyl-3-(1-ethoxyl)-quinoxaline as well as a preparation method and application of the 1-oxygen-2-hydroxylmethyl-3-(1-ethoxyl)-quinoxaline with the formula (I) structure. The product (I) is prepared by the following steps: 1, 4-dioxy-3-methyl-2-(1-ethoxyl) quinoxaline is obtained by reduction of raw material mequindox; mixing the product with acetic anhydride and pyridine to obtain 1,4-dioxy-2-(1-ethoxycarbonyloxyethyl)-3-methyl-quinoxaline; then under the effect of the acetic anhydride,1-oxygen-2-(1-ethoxycarbonyloxyethyl)-3-(1-ethoxycarbonyloxymethyl)-quinoxaline is obtained; 1,4-dioxy-2-(1-hydroxyethyl)-3-hydroxylmethyl -quinoxaline is obtained after oxidation by oxidant and hydrolysis by alkali liquor; and under the reduction by a reductant, the product (I) is obtained through reduction of a reductant, wherein the product (I) can be used as a residual marker for mequindox metabolized in a targeting animal body or used as a standard or a reference sample to determine mequindox residual in animal derived food.

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