The invention relates to a nickel-based intermetallic compound material suitable for an inert anode in an oxide and hydroxide fused salt system, and particularly relates to nickel-based nickel aluminum, nickel silicon and nickel aluminum silicon intermetallic compounds and an application thereof as inert anode materials in the oxide and hydroxide fused salt. A nickel-based intermetallic compound inert anode is characterized in that the inert anode is applied to oxide or hydroxide flux. The mass ratio of the raw materials is as follows: x% of Ni, y% of Al and z% of Si, wherein x is equal to 100-y-z; y is more than or equal to 1 and is less than or equal to 30; and z is more than or equal to 1 and is less than or equal to 20. The methods provided by the invention have the beneficial effects that the inert anode made of nickel-based nickel aluminum, nickel silicon and nickel aluminum silicon intermetallic compounds has the characteristics of high stability, high conductivity, easiness in processing and low cost, and is different from other metallic anodes and oxide ceramic anodes.