The invention discloses a pesticide composition containing spinetoram and neonicotinoid insecticide, which comprises active components composed of a first active component and a second active component, wherein the first active component includes spinetoram and the second active component includes neonicotinoid insecticide selected from imidaclprid, acetamiprid and thiamethoxam, the weight ratio between the first active component and the second active component is (1:20) : (30: 1). The composition can be prepared to be formulations allowed in agriculture such as a water dispersible granule, wettable powder, a suspending agent, an emulsifiable concentrate or a microemulsion. According to the pesticide composition containing spinetoram and neonicotinoid insecticide, the components are reasonable, the insecticidal effect is good, the pesticide cost is low, and the activity and insecticidal effect are not a simple composition of each component activity, compared with the existing single preparation, the pesticide composition containing spinetoram and neonicotinoid insecticide has the advantages of remarkable insecticidal effect, and also prominent synergistic effect, good security, accordance with the safe requirement of pesticide preparations, and good preventing effect for vegetable thrips.