The invention relates to medicine for treatment of leukemia-induced hepatosplenomegaly, which is prepared with traditional Chinese herbs as raw materials. Weasel powder, chicken eggshell powder, jujube, angelica, ligusticum wallichii, rhizoma sparganii with vinegar, rhizoma curcumae with vinegar, fried peach kernel, ground beeltle, salviae miltiorrhizae, vinegar-baked bupleurum root, pericarpium citri reticulatae, vinegar-baked rhizoma cyperi, citrus chirocarpus, citron, oldenlandia diffusa and fried pangolin are carefully selected, well mixed and crushed into powder of 100-120 meshes, and the powdered product is prepared with adhesive in a conventional method after sterilization and disinfection. The medicine has the effects of promoting blood circulation, removing blood stasis, eliminating stagnation and protecting the liver, and also has significant effects on the leukemia-induced hepatosplenomegaly, and fewer toxic and side effects can be caused.