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发明公开
CN102590515A 艰难梭菌外毒素A检测试剂盒及组成该试剂盒的单克隆抗体 失效 - 权利终止

艰难梭菌外毒素A检测试剂盒及组成该试剂盒的单克隆抗体
摘要：
本发明属于生物技术领域，公开了艰难梭菌外毒素A检测试剂盒及组成该试剂盒的单克隆抗体。一种检测艰难梭菌外毒素A的试剂盒，包含两种抗艰难梭菌外毒素A羧基端抗原的单克隆抗体，分别为保藏号为CGMCC No.4979的杂交瘤细胞产生的抗艰难梭菌外毒素A羧基端抗原的单克隆抗体以及辣根过氧化物酶标记的由保藏号为CGMCC No.4980的杂交瘤细胞系产生的抗艰难梭菌外毒素A羧基端抗原的单克隆抗体。本发明提供的艰难梭菌外毒素检测试剂盒，通过使用两株高亲和力的配对单抗，使检测艰难梭菌的灵敏度有了显著提高。
摘要（英）：

The invention belongs to the field of biotechnology, and discloses a clostridium difficile exotoxin A test kit and monoclonal antibodies in the clostridium difficile exotoxin A test kit. The kit for testing clostridium difficile exotoxin A comprises two monoclonal antibodies capable of resisting clostridium difficile exotoxin A c-terminus antigens. The two monoclonal antibodies are respectively the monoclonal antibody capable of resisting the clostridium difficile exotoxin A c-terminus antigen and produced by hybridoma with the preservation number of CGMCC No.4979, and the monoclonal antibody labeled by a horse radish peroxidase and produced by hybridoma with the preservation number of CGMCC No. 4980. According to the clostridium difficile exotoxin A test kit provided by the invention, by the two monoclonal antibodies with high affinity, the sensitivity in the detection of clostridium difficile is remarkably improved.

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