A system and method enable handover from a DC-HSUPA-capable node in a cellular wireless network to a non-DC-HSUPA-capable node. According to various aspects of the present disclosure, a handover may implement a legacy serving cell change procedure or an enhanced serving cell change procedure. In either case, signaling from the network to user equipment includes information to enable the user equipment to change or remove an Active Set when undergoing a handover from a cell with two uplink carriers and accordingly two Active Sets, to a cell with one uplink carrier and accordingly one Active Set.