The invention relates to a polymer modified lipid material and application thereof. The lipid material is a compound shown in the formula I, or a compound shown in the formula 9 or a physiologically acceptable salt thereof, wherein n is an integer in the range of 5-500, m is an integer in the range of 2-12, and p is an integer in the range of 1-8. The invention also relates to an intermediate of the compound shown in the formula I, an application of the compound shown in the formula I and an administration carrier prepared by the compound shown in the formula I. The administration carrier provided by the invention can be used for increasing the concentration of an anti-cancer medicine on a target part, simultaneously reducing the toxin or side effect on a non-target part and increasing the therapeutic index of the medicine.