The invention discloses a door and window handle lock, which comprises a handle, a lock body with a rotating part and a rotating shaft with a polygonal section. The polygonal rotating shaft is inserted into polygonal installation holes of the handle and the rotating part to connect the rotating part with the handle, and spring sheets capable of clamping the rotating shaft into the polygonal installation holes are arranged at inner corners of the polygonal installation holes of the handle and the rotating part. As the spring sheets are installed in gaps among the rotating shaft and the installation holes, the rotating shaft is clamped in the installation holes, loosening due to the gaps is prevented, and the door and window handle lock is firm and reliable in assembly, simple in structure and convenient in assembly, and has fewer parts.