An embodiment of the invention discloses an open bench inter-hole differential control blasting method, which relates to the technical field of mining and is invented for solving the problems that resulting fragmentation degree needs to be better, blast vibration damage needs to be reduced, and large-scale blasting needs to be implemented effectively. The method includes: subjecting blast holes in a same row to inter-hole differential accumulation according to delay time of 1-5ms per hole-pitch meter, and performing inter-hole differential interval blasting; subjecting the blast holes in all rows to inter-hole differential accumulation according to the delay time of 10-30ms per row-spacing meter, and performing inter-row differential interval blasting; and filling at least one of the blast holes with a plurality of priming bombs or spaced charged explosive, and performing intra-hole differential interval blasting. The method is applicable to open-pit mining, and also applicable to large-scale earth-rock excavation engineering, large-scale hydropower engineering, large-scale civil engineering, large-scale underground workshop excavation and the like.