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发明公开
CN102617661A 一种分离纯化二苯乙烯苷单体的方法 无效 - 撤回

一种分离纯化二苯乙烯苷单体的方法
摘要：
本发明提供一种分离纯化二苯乙烯苷单体的方法，其采用高速逆流色谱法，以乙酸乙酯、乙醇和水组成的三元溶剂体系作为分离溶剂系统，从二苯乙烯苷粗品中分离提取二苯乙烯苷单体。本发明的分离纯化方法采用半制备型高速逆流色谱仪对二苯乙烯苷粗品进行分离纯化，并通过三元溶剂体系，利用高速逆流色谱的回收率高和无不可逆吸附的特点，能够大规模的制备二苯乙烯苷单体，制备量能够达到克量级；且制得的二苯乙烯苷单体纯度高，达99％以上，以该高纯度的二苯乙烯苷单体为原料，能够制得二苯乙烯苷单体标准样品。本发明方法能够适合于不同的二苯乙烯苷粗品，具有技术工艺先进、分离效率高、回收率好、产品纯度高、制备量较大等优点。
摘要（英）：

The invention provides a method for separating and purifying stilbene glucoside monomers, which adopts high-speed counter-current chromatography and uses a ternary solvent system composed of ethyl acetate, ethanol and water as a separation solvent system to separate and extract the stilbene glucoside monomers from a crude stilbene glucoside product. The separating and purifying method of the invention adopts a semi-preparative high-speed counter-current chromatograph to separate and purify the crude stilbene glucoside product, allows the crude stilbene glucoside product to go through the ternary solvent system, and utilizes the characteristics of high recovery rate and no irreversible adsorption of the high-speed counter-current chromatography to massively prepare the stilbene glucoside monomers, and the preparation amount can reach a gram magnitude; and the purity of the prepared stilbene glucoside monomers, which is high, reaches above 99%, and a standard sample of the stilbene glucoside monomers can be prepared with the high purity stilbene glucoside monomers as a raw material. The method of the invention is suitable for different crude stilbene glucoside products, and has the advantages of advanced technology, high separation efficiency, good recovery rate, high product purity, large preparation amount and the like.

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