The invention relates to a control system and method of a full-automatic knitting machine. The control system comprises a movement control unit and a human-machine interface, wherein the movement control unit is electrically connected with the human-machine interface and comprises a machine head control module and a machine tool control module, and each of the human-machine interface, the machine head control module and the machine tool control is internally provided with an ARM (access random memory) chip; the machine head control module is electrically connected with a first driving unit and the machine tool control module is electrically connected with a second driving unit; the machine head control module receives a signal of the human-machine interface and then controls the first driving unit; and the machine tool control module receives a signal of the human-machine interface and then controls the second driving unit to operate. The control system disclosed by the invention has the advantages of full automatic operation, simple structure and lower cost, and the control method is simple, convenient to operate and high in production efficiency.