The invention relates to a monolauryl phosphate-containing lithontriptic for litholysis of cholesterol gallstone. The monolauryl phosphate-containing lithontriptic comprises methyl tertiary butyl ether and monolauryl phosphate, wherein based on 1mL of methyl tertiary butyl ether, the mass of used monolauryl phosphate is in a range of 0.05 to 0.60g. The monolauryl phosphate-containing lithontriptic can correspondingly reduce saturated vapor pressure and smell irritation of methyl tertiary butyl ether and thus the novel monolauryl phosphate-containing lithontriptic can be used in non-operative clinical therapies for patients suffering from cholesterol gallstone.