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发明授权
CN102627687B 中华绒螯蟹促性腺释放激素类似物及其制备方法和应用 失效 - 权利终止

中华绒螯蟹促性腺释放激素类似物及其制备方法和应用
摘要：
本发明涉及分子生物学和生物技术领域，公开了中华绒螯蟹促性腺释放激素类似物，氨基酸序列分别为QSYHFSHGWKP与QAYHFSHGWKP。这两种亚型的中华绒螯蟹的促性腺释放激素类似物与其他物种GnRH进行进行氨基酸序列比对，结果显示，具有相似的氨基酸保守位点，序列结构与无脊椎动物GnRH相类似；并且具有与脊椎动物的GnRH相似的功能，可以刺激卵母细胞生发泡破裂，对蟹卵母细胞最终成熟有显著促进作用，对于中华绒螯蟹人工催熟具有重要应用价值。
摘要（英）：

The invention relates to the fields of molecular biology and biological technology, and discloses Eriocheir sinensis GnRH (gonadotropin-releasing hormone) analogues with respective amino acid sequence of QSYHFSHGWKP and QAYHFSHGWKP . Compared the the amino acid sequences of the two subtypes of Eriocheir sinensis GnRH analogues with those of the GnRH of other species, the results show that the former and the latter have similar amino acid conservative sites; the the sequence structures of the Eriocheir sinensis GnRH analogues are similar to that of invertebrate GnRH; and the Eriocheir sinensis GnRH analogues have similar functions as vertebrate GnRH, can stimulate breakdown of oocyte germinal vesicle and have distinct stimulative effect on crab oocyte maturation and important application value for artificial ripening of the Eriocheir sinensis.

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