The invention relates to medicinal and edible selenium-supplementing oral liquid, which is made by adding, by 100kg for processing, 85kg of water in eight traditional Chinese medicines including bunge cherry seeds, fructus alpiniae oxyphyllae, semen ziziphi spinosae, coix seeds, Siraitia grosvenorii, fructus Lycii, rhizoma Dioscoreae and semen cassiae, soaking for 60 minutes, , decocting for 30 minutes filtering, storing filtrate, adding 60kg of organic acid solution in residue, decocting for the second time for 30 minutes, storing filtrate, adding 50kg of water in residue, decocting for the third time for 20 minutes, storing filtrate, adding 50kg of water in residue, decocting for the fourth time for 20 minutes, mixing all the filtrates, adding sodium selenite enhancer, heating and boiling for 15 minutes for chelation and complexation, adding potassium sorbate, sweetener, corrective and the like prior to mixing for 15 minutes after slightly cooling the filtrates, filtering, bottling, capping, sealing, visually inspecting, packaging and inspecting before storage. The medicinal and edible selenium-supplementing oral liquid has the advantages of high bioavailability and few side effects.