The invention relates to a composition with a good curative effect by aiming at various osteoarthritis symptoms, and is characterized in that the composition contains 1-50 parts of shark chondroitin sulfate, 1-50 parts of dimethyl sulfone, 1-50 parts of glucosamine hydrochloride, 1-10 parts of vitamin C, 1-10 parts of sodium molybdate and 1-10 parts of manganese sulfate, and other nutrition components, such as Beta- sitosterol, vitamin K, vitamin E, immunoglobulin, vitamin D and the like can be added. The composition disclosed by the invention can be prepared into various oral dosages by pharmaceutically acceptable carriers and additives, and the composition has good treating effect on various bone and arthrosis pain/ chronic pain diseases.