The invention provides a traditional Chinese medicine compound preparation with anti-alcohol liver protection activity, and a preparation method of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation comprises cacumen tamaricis, white hyacinth bean, radix puerariae, schisandra chinensis and liquorice. The traditional Chinese medicine compound preparation has the beneficial effects the compound preparation is pure traditional Chinese medicine oral administration preparation, is prepared by matching of medicines, has stronger synergistic effect, can resist lipid peroxidation of membrane of the liver and obviously protect alcoholic liver injury, and is remarkable in effects and free from toxic or side effect.