The invention relates to a wave power generation device, which mainly makes use of buoyancy of seawater and thrust of waves to drive buoys to swing vertically, so as to produce driving force, and then the vertically swung driving force is converted into one-way output power through a reverse mechanism, the power is transferred and amplified by a speed increaser and is further transferred to a power wheel by an output end; while two ends of a rotary shaft of the power wheel are provided with flywheels, and a rotating wheel for transferring power is arranged on a rotary shaft so as to transmit the power to a power generator. The wave power generation device adopts a simple and convenient structure to realize conversion of natural resources, and convert the thrust brought by the natural resources into power, thus, the resources can be utilized continuously, the structure is simple, and the implementation cost is low. In addition, the rotating wheel is arranged on the rotary shaft of the wave power generation device to correspondingly transmit the excessive power to an air compressor, the air compressor drives an air motor by storing air to aid transmission power wheels, thus, power can be generated during slack tide of waves, and continuous power supply by the wave power generation device can be ensured.