The invention discloses an agricultural sterilization composition containing SYP-1620 and oomycete prevention and treatment sterilization agents. The agricultural sterilization composition comprises effective active ingredients of SYP-1620 as first active ingredients and oomycete prevention and treatment sterilization agents as second active ingredients selected from metalaxyl, myclobutanil, fosetyl-aluminum, cymoxanil and flumorph, and the weight ratio of the first active ingredients to the second active ingredients is 1:(20-5):1 and is preferably 1:(10-2):1. The composition can be prepared into agriculture allowable water dispersing granules, wettable powder, suspension and suspension seed coatings. The agricultural sterilization composition has the advantages that the ingredients are reasonable, the sterilization effect is good, the medication cost is low, and in addition, the activity and the sterilization effect are not simple accumulation of the activity and the effect of each ingredient. Compared with the existing single preparation, the agricultural sterilization composition has the advantages that the sterilization effect is obvious, in addition, the obvious synergistic effect is realized, no pollution is caused on crops, the safety is good, the safety requirement of pesticide preparation is met, and the agricultural sterilization composition has the obvious prevention and treatment effects on crop downy mildew, epidemic diseases, pythium debaryanum and powdery mildew.