The invention discloses a metaflumizone-containing insecticide composition. A first active ingredient of the composition is metaflumizone; a second active ingredient is selected from cartap and bisultap of nereistoxin insecticides; and the weight ratio of the first active ingredient to the second active ingredient is 1:60. The insecticide composition can be prepared into formulations such as water dispersible granules, a suspending agent, wettable powder, microemulsion or emulsion in water. The insecticide composition can be used for controlling rice-stem borer and Cnaphalocrocis medinalis; the insecticide composition has reasonable components and a good insect-killing effect, is low in pesticide cost, is safe to crops, and meets the safety requirements of pesticide preparations; the activity and insect-killing effect of the composition are not equal to the simple superposition of the activities of the components, and the composition has a remarkable synergistic effect; and the resistance can be delayed.