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发明公开
CN102666839A 具有提高的生产丁醇能力的重组微生物和使用其生产丁醇的方法 有权 转让

具有提高的生产丁醇能力的重组微生物和使用其生产丁醇的方法
摘要：
本发明涉及具有提高的生产丁醇能力的重组微生物，和使用其生产丁醇的方法。更具体来说，本发明涉及生产丁醇的能力通过操纵它们的代谢网络而提高的重组微生物和使用其生产丁醇的方法。该具有提高的生产丁醇能力的重组微生物包括在具有参与乙酰CoA和丁酰CoA生物合成路径的酶的编码基因的宿主微生物中，编码将乙酰CoA转化成乙酸的酶的基因被删除。通过操纵微生物的代谢流获得的重组微生物能够以高选择性地生产丁醇，因此可用作用于生产工业溶剂和运输燃料的微生物。
摘要（英）：

The present invention relates to a recombinant microorganism with an increased butanol production ability, and a preparation method of butanol using the same, and more specifically, to a recombinant microorganism of which the butanol production ability is increased by the manipulation of metabolic pathways, and a preparation method of butanol using the same. The recombinant microorganism with an increased butanol production ability according to the present invention is characterized in that a gene encoding an enzyme which converts acetyl CoA into acetate is deleted in a host microorganism having a gene encoding enzymes involved in the biosynthetic pathway into acetyl CoA and butyryl CoA. Since the recombinant microorganism according to the present invention obtained by the manipulation of the metabolic flow of a microorganism can selectively produce butanol with a high efficiency, it is useful as a microorganism producing an industrial solvent and a transportation fuel.

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