The invention relates to a fly killing composition which is composed of an original drug component A, an original drug component B and an auxiliary component C, wherein the total weight of the component A and the component B is 0.03-10% of that of a pesticide composition; the original drug component A is fipronil; and the original drug component B is pyrethroid integrating high-efficiency knockout performance and lethal performance. According to the invention, the response speed is obviously increased through high contact toxicity of the pyrethroid; with the help of high-efficiency stomach poisoning action and synergistic action of the fipronil, the killing speed is further accelerated; simultaneously, the lethality is obviously increased; a more efficient drug is provided for controlling vector-borne infection in environments required for residential production and living and for protecting people health; in addition, while obviously increasing the fly killing efficiency, resistance is delayed, and the drug cost is saved.