The invention discloses a Chinese medicinal compound with a tongue squamous cell carcinoma resisting effect and a preparation method thereof. The Chinese medicinal compound is prepared from the following raw materials in parts by weight: 10-20 parts of waxgourd seed, 12-24 parts of rhizoma pinellinae praeparata, 10-20 parts of arisaema cum bile, 12-24 parts of indian iphigenia bulb, 10-20 parts of ternate buttercup root, 10-20 parts of wild buckwheat rhizome, 10-20 parts of heartleaf houttuynia herb, 15-30 parts of hairyvein agrimonia herb and bud, 12-24 parts of sappan wood, 15-30 parts of safflower, 10-20 parts of straight ladybell root, 10-20 parts of fragrant solomonseal rhizome and 10-20 parts of dwarf lilyturf root. The Chinese medicinal compound with the tongue squamous cell carcinoma resisting effect provided by the invention is prepared by selecting raw materials according to the traditional Chinese medicine theory and the pathogenesis of tongue squamous cell carcinoma, and components are blended scientifically and reasonably; and as proved by a pharmacodynamics experiment result, the Chinese medicinal compound can contribute to remarkably lowering the content of PGE2, has a very good tongue squamous cell carcinoma resisting effect, is free from untoward effects after long-term use, and can be developed into a new generation of tongue squamous cell carcinoma resisting medicament.